Samcyprone™ is being studied for the treatment of cutaneous warts, benign epidermal tumors caused by human papillomaviruses (HPVs). They are extremely common, being experienced by most people at some time during their lives. Although most warts will spontaneously disappear without treatment, treatment of these lesions is sought to prevent recurrence. There are many different treatment modalities for warts including physical destruction (cryotherapy, surgical removal, carbon dioxide laser), chemical destruction (salicylic acid, glutaraldehyde, podophyllin, cantharidin, bleomycin) and immunomodulation (interferons, retinoids, contact immunotherapy). However, treatment of warts is complicated by low success rates, prolonged duration of therapy, and the potential for recurrence. It is well established that cell-mediated immune response plays a major role in controlling HPV infections. Therefore, treatment techniques such as immunotherapy have been used to activate the immunologic response to HPV.